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Software and Platforms
A unified ecosystem of interpretable AI, systems biology, and translational modeling frameworks.
PreCSN and HUMANOID™ integrate human cohorts, multi-omic data, and AI-enabled systems modeling to build reproducible, cohort-anchored NAMs that enable transparent benchmarking, digital biomarker discovery, and therapeutic insight.
AXIOM-Bio
Abstract eXpression Inference and Ontology-free Modeling
A foundational systems-biology framework that identifies biological thresholds, feedback logic, and state-transition rules governing health and disease.
Built through a decade of mechanistic and computational studies and summarized here: DOI: 10.5281/zenodo.17459815
COMPASS™
COMPosite Activity Scoring System
A coding-free platform that transforms raw expression data into deterministic pathway activity scores for objective model benchmarking and human cohort anchoring through transfer learning.
Used to integrate AI/ML into organoids and benchmark their humanness, relevance and fidelity against human tissues.
Used to integrate AI/ML into organoids and benchmark their humanness, relevance and fidelity against human tissues.
TRUST-NAM™
Translational Relevance, Utility, Scalability, and Trustworthiness of NAMs
A quantitative guardrail framework that benchmarks New Approach Methodologies (NAMs) against human biology using transfer learning. TRUST-NAM™ is implemented using human cohort–anchored transfer learning, deterministic pathway scoring (COMPASS™), and quantitative guardrails that generate transparent report cards of humanness, relevance, and fidelity, enabling reproducible model evaluation and decision-grade translational science.
PMID: Coming soon
CANDiT
Cancer-associated Nodes for Differentiation Targeting
A mechanistic prioritization engine that identifies reversible and druggable regulators controlling cancer cell plasticity, fibrosis, and immune dysfunction.
FORWARD
Framework for Outcome-based Research and Drug Development
A human cohort–anchored platform that extracts regenerative and disease-reversal logic from longitudinal multi-omic datasets to guide therapeutic prioritization.
SMaRT
Signatures of Macrophage Reactivity and Tolerance
A systems framework defining continuum states of macrophage adaptation, resilience, and reversibility across inflammatory and degenerative diseases.
Applications span colitis, immunometabolism, immuno-oncology, fibrosis, and neurodegeneration.
Applications span colitis, immunometabolism, immuno-oncology, fibrosis, and neurodegeneration.
Chronobiology (coming soon)
Liver fibrosis (coming soon)
Arthritis (coming soon)
Alzheimer’s disease (coming soon)
PICASSO™
Phenotype-Informed Clinical Abstraction for Systematic Simulation and Outcomes
An interpretable AI framework for building cohort-anchored NAM ecosystems through multi-omic integration, disease subtyping, and trajectory mapping.
GENIE
Generative Engine for Network Intelligence and Exploration
A high-performance computational engine that powers the PreCSN ecosystem, enabling scalable analysis, AI-assisted discovery, and seamless integration of multi-omic data, biological knowledge, and translational modeling workflows.
A high-performance computational engine that powers the PreCSN ecosystem, enabling scalable analysis, AI-assisted discovery, and seamless integration of multi-omic data, biological knowledge, and translational modeling workflows.
